Kepley K9 Science

Why do dogs sniff the ground so thoroughly before they can have a bowel movement? That probably isn’t the first question you would think a life-science lab would be interested in, but the team behind Kepley K9 finds that it is crucial to understanding our best friends’ needs. As anyone who has owned a dog can attest, this sniffing can become frustrating for the owner, especially in miserable weather or when under erratic scheduling, but also for the dog. Dogs are intrepid smellers that search for a specific family of molecules that trigger gastrointestinal neurobiology and physiology via olfaction. Put simply, they are looking for the scents they need to trigger the urge to defecate.

Unfortunately, these specific scents are becoming increasingly rare in today’s sanitized urban environments in which dogs find themselves. Kepley K9 Strategic Scent Stimulant seeks to solve this issue by providing an easy-to-use formulation of specific organic aromatic amines and botanicals to mimic the scents dogs seek, allowing for faster defecation and less searching.

How Humans View Their World vs How Dogs View Their World

To comprehend further how this works, we must first understand how amazing the canine sense of smell is and how dogs see things compared to our own sense of the world. Researchers suggest that the phenomenal scent sensitivity of dogs would be capable of detecting a single droplet in 20 Olympic-sized pools (Angel et al., 2016). Dogs have up to 300 million olfactory receptors in their noses, whereas humans have only about six million. As can be imagined, such exceptional scent awareness would change their very perception of the world as we know it.

Human view of a typical indoor space...
Canine view with exceptional scent awareness.
Human view of a urban outdoor space...
Canine view with exceptional scent awareness.

It becomes evident how distracted dogs can become when bombarded by the odors, sounds, and sights of these environments. Often such diversions are time-consuming and frustrating to the owner and the dog seeking the gastrointestinal-stimulating molecule typically needed to “inspire” relief from a full colon.

Kepley K9 Strategic Scent Stimulant combines the same organic and botanical molecules that settle on the ground and break down over time in every climate, country and hemisphere offering the instinctively sought olfactory cues dogs are seeking as they sniff. Once Kepley K9 Strategic Scent Stimulant is applied, a chemosensory plume emanates from the dog’s paw, stimulates a neural response, and accelerates the final peristalsis phase, resulting in defecation. It is easily applied to the dog’s front paw before being allowed or led to the relief area (see below).

Directions for Use:

Shake well before use.
Place one (1) drop on dog's front paw.
Immediately allow access to relief location.
Allow for proper outdoor time.

Kepley K9 Strategic Scent Stimulant is entirely safe to use routinely, and most dogs grow confident with prompt excretion. It is formulated to disperse quickly from the dog’s paw, and lingering scents typically promote a calming effect of “being outdoors” as they evaporate following the initial gastronomic response.

Olfaction-triggered Gastrointestinal Defecation Neurobiological Network

(WHY IT WORKS)

The Kepley K9 Strategic Scent Stimulant chemosensory odorants contain ubiquitous yet specific molecules that immediately focus and reassure the dog of being “outside” when given access to the appropriate location – typically “inspiring” the dog to rapidly relive itself. Exposure to these scents stimulates dogs’ gastrointestinal chemistry, final peristalsis and sphincter release.

Kepley K9 Strategic Scent Stimulant scent molecules release in a plume of scent that wafts into the dog’s sensory glands. This allows the dog to focus, with less distraction from the environment (A1). The scent molecules bind to the olfactory receptors (A2). The olfactory nerves (B) then transfer a mosaic of responses directly to the brain (C). The brain then triggers peristalsis and the dog’s impulse to relieve the colon and relax the sphincter (D).

By utilizing a proprietary blend of botanicals and derivatives of amino acids of organic origin, Kepley K9 Strategic Scent Stimulant provides dogs with the chemosensory molecules needed to stimulate defecation.

Scientifically-validated Field Evaluations

(REAL-WORLD RESULTS)

Owners’ perceived efficacy of the stimulant solution; During each test of the trial, the volunteer evaluators were asked to rank the perceived efficacy of the solution in terms of time to defecation compared to untreated norms. Faster defecation times were observed 75% of the time (black); slower defecation was perceived 4% of the time (red); and no observed changes were perceived 21% of the time (white).

A) The average control 321 time (untreated) to defecation was 300-seconds. One drop of stimulant solution was placed on 322 the dog’s front paw and recorded as T0, and the time required for defecation (TD) was recorded 323 for each test. The average TD across all observations (n=88) was 107 seconds (64% faster than 324 the untreated TD); the average of the three fastest TD was 49 seconds (86% faster than the 325 untreated TD);

B) Indicates the breed, sex, weight, age, setting and preferred elimination 326 surface and location.

C) Includes average untreated TD, treated TD and owner perceptions 327 from the field questionnaire.

Field trials with four breeds weighing less than 50-lbs (Yorkshire Terrier, Miniature Doberman, Jack Russell Terrier, and Beagle); A) The average untreated elimination time (red) for each dog was established by the field evaluator; Each trial consisted of seven unique tests; One drop of stimulant solution was applied to the dog’s front paw at T0, and the evaluator measured the time; Upon defecation, the time was recorded as TD; Gray bars represent the average TD across the seven-day trial; B) Indicates the animal information average untreated/treated elimination times, and percent change in TD vs. untreated tests (2018).

Field trials with five breeds weighing greater than 50-lbs (Golden Retriever, Weimaraner Pit Bull Mix, Rottweiler Australian Shepherd Mix, Black Labrador, and Rhodesian Ridgeback); A) The average untreated elimination time (red) for each dog was established by the field evaluator. Each trial consisted of seven unique tests. One drop of stimulant solution was applied to the dog’s front paw at T0, and the evaluator measured the time. Upon defecation, the time was recorded as TD. Gray bars represent the average TD across the seven-day trial; B) Indicates the animal information, average untreated/treated elimination times, and percent change in TD vs. untreated tests. (2019).

Kepley K9 is a branch of Kepley BioSystems, experts in chemo-sensory attraction and resulting animal behaviors. The Kepley K9 Strategic Scent Stimulant technology originates from National Science Foundation supported research into created a synthetic and sustainable crustacean bait, branded as OrganoBait. It became evident that the analytical discoveries and understanding of olfactory responses that resulted in this project could be translated to other species. To learn more about OrganoBait and other Kepley BioSystems projects, please visit www.kepleybiosystems.com